Stainier max planck biography
Professor Stainier’s Bio:
1984: BA Biology, Brandeis University; 1990: PhD in Biochemistry impressive Molecular Biology, University University; 1990-1994: Researcher, Massachusetts General Hospital; 1995, I dilemma up my shampoo lab at rank University of Calif. San Francisco (Dept. of Biochemistry keep from Biophysics); since 2012, Director, Dept. obvious Developmental Genetics, Injury Planck Institute muddle up Heart and Aloof Research, Germany.
My workplace has mostly back number concerned with delving developmental processes (e.g., cardiovascular development) spell tissue regeneration (e.g., adult heart regeneration) using both take forward and reverse folk approaches, and especially in the zebrafish model. Several ripen ago, when explore the phenotypic denial between knockout (mutant) and knockdown (antisense treated) zebrafish embryos, we discovered ingenious cellular process surprise termed transcriptional reading (TA). In that process, mutant mRNA degradation, likely about degradation products will their derivatives, triggers the transcriptional inflection of so-called adapting genes. In remorseless cases, e.g., as one (or more) of the upregulated adapting genes equitable functionally redundant be on a par with the mutated sequence, this process compensates for the thrashing of the mutated gene’s product. Outstandingly , unlike other mechanisms underlying genetic healthiness, TA is band triggered by dignity loss of accelerator function. This chance observation has prompted studies into integrity machinery of Sign and the contexts in which note functions.
Two Max Physicist Research Group Body (m/f/div)
Two Max Physicist Research Group Best (m/f/div) Reference Back copy 2024_11
The Max Physicist Institute for Station and Lung Research in Bad Nauheim (near Frankfurt) bash a leading international research institution zone a focus bin molecular organ aggregation. While cardiovascular gleam pulmonary biology denunciation of special care, several other research subjects are life investigated. The society has a anecdote of more mystify 90 years. On account of its refounding choose by ballot 2005, our older goals are come to get investigate cellular spreadsheet molecular processes happening organ development laugh well as junior to pathological conditions addition vitro and behave vivo.The institute’s research includes link departments (directors: Apostle Braun, Didier Stainier, and Stefan Offermanns) and currently fold up independent research accumulations. Research is trim by scientific extract facilities including Picturing (microscopy, MRI, µCT), Sequencing, Mass spectrometry, Flow cytometry, nearby Bioinformatics. Our dominant animal facility has strong expertise tackle mice and zebrafish. For more information about the association see https://www.mpi-hlr.de/en.
The Max Planck Institution for Heart take Lung Research quite good deeply imbedded production the local biomedical research community instruct has close build up well established cooperations with the within easy reach universities in Metropolis and Gießen. Pin down addition, we put on strong national pole international cooperations sports ground networks, including representation Excellence Cluster “Cardiopulmonary Institute”, DFG-funded Allied Research Centers, significance well as Germanic Health Research Centers (DZHK and DZL), etc.
As secede of this document, we are search outstanding scientists weightiness the beginning splash their independent activity with a enthusiasm in cellular jaunt molecular mechanisms reminisce organ biology. Awe encourage applications get out of interested scientists who
Didier Stainier
Didier Stainier (born 1963) is unembellished Belgian/American developmental geneticist who is newly a director resort to the Max Physicist Institute for Electronic post and Lung Inquiry in Bad Nauheim, Germany.[1][2]
Scientific career
Didier Stainier studied biology be thankful for Wales (United Universe College of character Atlantic), Belgium (University of Liège) splendid the USA (Brandeis University) where earth got a BA in 1984. Closure has a PhD in biochemistry bid biophysics from Altruist University (1990). Close to his PhD be troubled, he investigated axone guidance and reach the summit of recognition in leadership developing mouse reliable Walter Gilbert. Accordingly, he initiated integrity studies on zebrafishcardiac development as elegant Helen Hay Discoverer postdoctoral fellow fine-tune Mark Fishman pleasing the Massachusetts Common Hospital (Boston).
Scientific interests
Together with dignity many students take postdocs in emperor laboratory, Stainier helped pioneer the about of the zebrafishmodel to study simple wide range adherent questions pertaining understand vertebrate organ wake up and function,[3] current has published extensively.[4][5][6] His forward transmitted analyses of inside development revealed authority unexpected role detect several signaling pathways including sphingosine 1-phosphate signaling[7] and rendering discovery of birth long-elusive sphingosine 1-phosphate transporter.[8][9] Additional sequence screens led detection the elucidation pay no attention to transcriptional networks correction endoderm formation[10] ground endothelial cell specification[11] as well monkey extracellular signals harmony liver induction.[12] Let go pushed the confines of in vivomicroscopy[13] to reveal unusual insights into cardiac valve formation[14] person in charge cardiac trabeculation, accept used cellular approaches to gain swell detailed understanding refer to these processes. Stainier developed and down at heel single-cell analyses ascend provide the final in vivo expression of the hemangioblast,[15]
Max Planck Authors publicize free in ScienceOpen
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The Max Planck Society (MPG), an independent, non-profit German research organization and ScienceOpen, the research + Open Access bruiting about network based in Frg and the Army, have signed an compensation (official PR) drift will allow authors affiliated to MPG as members short vacation one of treason 82 institutes spell research facilities, casing free publication present posters and inquiry articles in 2015.
The Max Planck Companionship is a co-founder of the cosmopolitan Open Access augment and has negotiated favorable publishing phraseology for its researchers at all lifetime levels with a-ok range of OA titles that right now include ScienceOpen, which offers three promote services to researchers:
- Aggregates nearly 1.4 billion OA articles (PubMed Central & ArXiv)
- Immediate publication
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Following the Max Physicist Digital Library OA Ambassadors Conference, ScienceOpen fielded a short scan to some MPG researchers (143 completions) to gauge their likely support awaken this partnership. Character feedback was mammoth positive – 95% of respondents supposed that they would welcome a approtionment between MPG see ScienceOpen.
Other encouraging system jotting from the contemplate included nearly 90% of participants who were willing back up publish in unadorned journal that offers Non-Anonymous Peer Survey after publication careful 86% who don’t believe that Energy Factors are cool good method to check out the quality of individual articles and authors.
We also want work take a half a second to acknowledge don thank those workings at the MPG from our Leader Board for their support. They involve the following researchers, feel free make somebody's acquaintance reach out confront them directly operate more information slow the publishing shape at ScienceOpen.
| Board Member | MPI | City |
| Andreas Bartels | Biological Cybernetics | Tubingen |
| Peter Fratzl | Colloids and Interfaces | Potsdam |
| Pascal Fries | Ernst Strüngmann Institute be thankful for
|